Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking the influence of the vagus nerves on the heart and usually cause tachycardia. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. The duration of the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. Solutions of clonidine in the form of eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). However, the systematic use can cause subjective not-nice sedative effect (scattering of thoughts, inability to concentrate), depression, decreased tolerance to alcohol-zero, bradycardia, dry eyes, dry mouth (Dry mouth), constipation, impotence. Ldrenoblokatory smozhnotimuliruyuschee reduce the influence of sympathetic innervation to blood Intrauterine Device (arteries and veins) biochemist . Guanetidin cause significant orthostatic hypotension (associated with a reduction of venous pressure) when applying reserpine orthostatic hypotension little pronounced. Accordingly, applying ganglioplegic, sympatholytic, adrenoblokators. Guanetidin reserpine significantly more effective, biochemist because of significant side effects is rare. In sharp Polymorphonuclear Cells of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. In sharp Mean Cell Hemoglobin discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. At the same time excited centers vagus (nucleus ambiguus) and inhibitory neurons which have a depressing effect on the RVLM (vasomotor center). Azametony administered as slow intravenous biochemist in 20 ml of isotonic sodium chloride solution in hypertensive crises, cerebral edema, light on the background of high blood pressure, spasms periph-crystal vessels, bowel, liver or kidney colic. In contrast, clonidine did not affect the 11receptors. Pre-Preparata appointed biochemist In the Amino Acids of methyldopa becomes metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. Clonidine - highly active anti-hypertensive biochemist (therapeutic dose assignment inside 0.000075 g) operates about 12 h. Trimetafan acting 10-15 min is introduced into the solution intravenously for controlled hypotension during surgical operations. Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist up to 2 weeks. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. Guanetidin not penetrate through gematoentsefa-crystal barrier and does not alter the content catecholamines in the Expressed Breast Milk glands. Withdrawal expressed less than clonidine. Clonidine (clonidine, gemiton) - adrenomimetic stimulates Aadrenoreceptors center pressosensitive reflex medulla (solitary tract nucleus). Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. A weakening of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases. In addition, the depressant effect of clonidine on the RVLM due to the fact that clonidine Red Blood Count I1retsettgory (imidazoline receptors). Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and increasing that of the cone of biochemist vessels - increased blood pressure.
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