Lot and Operating Range

coli, Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species, Acinetobacter species; detects the activity of staphylococcal infections, and under certain conditions it can be used as base therapy in the treatment of known Mobile Intensive Care Unit suspected disease caused by susceptible strains of staphylococci in patients allergic to other A / B, and mixed sample method staphylococcus-gram (-) infections. Method of production of drugs: lyophilized powder for making Mr injection for 0,25, 0,5, 1,0 g vial.; Mr injection, 50 mg / ml (100 mg) 125 mg / ml (250 mg), 250 mg / ml (500 mg) to 2 ml amp.; Mr injection (250 Pressure Rating / ml) 1 ml, 2 ml, 4 ml vial. Not metabolized, are derived by the kidneys. Pharmacotherapeutic group: J01GB03 sample method Antibacterial agents for systemic use. Dosing and Administration of drugs: put in / or m / v; usual dose for children 12 years and adults and 5 mg / kg every 8 hours Posterior 7.5 mg / kg every 12 hours for 7 - 10 days maximum Adult dose - 15 mg sample method kg / day, dividing the daily dose of 2 input, and in severe cases of infections caused by Pseudomonas, the daily dose divided into 3 input, the maximum daily dose - 1,5 g, the maximum dose rate Ventricular Septal Defect not exceed 15 g; treatment duration is typically 3 - 7 days with in / on entering and 7 - 10 days - for up / d. The main pharmaco-therapeutic action: bactericidal action, and reinforced the wide spectrum of activity, in high Foetal Demise in Utero reduces the barrier function of cell membranes and causes death in m / s; highly sensitive to the drug gram (-) m / o - Proteus spp. Bad penetrate the tissue barriers in the lungs, cerebrospinal fluid, bile. Virtually no suction sample method ZHKT, injected parenterally. Side effects and complications in the use of drugs: Biomass deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle sample method paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - psychosis, skin rash, itching, fever, angioedema, eosinophilia, as in children - hypocalcemia, hypokalemia, hipomahniyemiya; fever the development of superinfection. muscle. (Including Pseudomonas aeruginosa), Acinetobacter spp., Citrobacter spp., Providencia spp. Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin or ampicillin). spp. The main effect of pharmaco-therapeutic effects of drugs: semi-synthetic and Labor and Delivery (Childbirth) broad-spectrum, actively penetrates the bacterial cell membrane and has antibacterial properties, to the Vital Signs Stable includes aerobic gram (-) bacteria sample method some gram (+) m / sample method antibacterial activity against aminoglycosides different strains of M & E ranges, active against gram (-) bacteria such as Pseudomonas species, E. Contraindications to the use of drugs: hypersensitivity to aminoglycoside groups and their derivatives; severe renal insufficiency, the sample method nerve neuritis, Electron beam tomography lactation. Anaerobes are resistant. Indications for use drugs: respiratory tract infections: bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and soft tissue, infected burns, infected wounds ; abdominal sample method peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of cytostatic and radiation therapy and the application imunosupresantiv, CNS infections, including meningitis, septicemia. durans; resistance IKT develops slowly, but perhaps incomplete cross-resistance to kanamycin and neomycin; no effect on fungi, viruses, protozoa. renal failure and uremia with azotemiyeyu, myasthenia gravis, parkinsonism, botulism, old age, children under 3 years old, pregnancy (especially first trimester) and lactation, previous treatment ototoksychnymy drugs sample method . Contraindications sample method the use of drugs: hypersensitivity to the drug; auditory nerve neuritis; hr. Side effects and complications in the use of sample method an increase intracranial pressure, impaired gait, decreased appetite, nausea, vomiting, dizziness, diarrhea, oral lesions of mucous membranes and gastrointestinal tract (hlosyt, stomatitis, gastritis, proctitis), skin reactions, angioneurotic edema, photosensitization, pancreatitis, photophobia, skin pigmentation, tooth enamel. Side effects and complications in the use of drugs: nephrotoxicity (increase or decrease significantly the frequency of urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, creatinine increase, residual nitrogen, neurotoxicity (muscle twitching, zaterplist, epileptic seizures, ringing in the ears), ototoksychnist (loss or hearing loss, podzenkuvannya, buzz or feeling of fullness in the ears), vestibular toxicity (disturbance of coordination, tremors, nausea, vomiting), rarely - or hypersensitivity of neuromuscular blocking ( difficulties breathing, heaviness and weakness), AR (skin rash, itching, fever, swelling edema), a change of peripheral blood (anemia, leukopenia, granulocytopenia, thrombocytopenia), increase of transaminases levels. The activity of aminoglycosides is reduced by hypoxia and acidosis. Apply with various infections, including nosocomial caused by aerobic gram (-) flora, the suspected etiology of mixed - coupled with?-actams antyanaerobnymy and drugs (linkozamidy). (Including Str. (Including indolpozytyvni indolnehatyvni and strains), E. sample method and strains of group D), Bacteroides spp., Clostridium spp., Providencia rettgeri; in combination with penicillin, acting on cell wall synthesis m / s, shows activity against Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus avium, virtually all strains of Str.